Exclusion of one pedigree affected by adult onset primary open angle glaucoma from linkage to the juvenile glaucoma locus on chromosome 1q21-q31.

نویسندگان

  • D Avramopoulos
  • G Kitsos
  • E Economou-Petersen
  • M Grigoriadou
  • D Vassilopoulos
  • C Papageorgiou
  • K Psilas
  • M B Petersen
چکیده

A locus for autosomal dominant juvenile onset primary open angle glaucoma (POAG) was recently assigned to chromosome region 1q21-q31. In the present study, a large Greek family with autosomal dominant adult onset POAG was investigated using microsatellite markers. Exclusion of linkage of the adult onset POAG gene to the region D1S194-D1S191 was obtained in this pedigree. Therefore, the data provide evidence that juvenile and adult onset POAG are genetically distinct disease entities.

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عنوان ژورنال:
  • Journal of medical genetics

دوره 33 12  شماره 

صفحات  -

تاریخ انتشار 1996